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Toxicity is extremely rare following administration of recommended dose. Nevertheless, liver damage is largely reversible if the patient is treated early, thus prompt medical attention is essential in all cases of suspected overdose even if there is no sign or symptom.
Acetaminophen overdose may cause liver failure.
High dose of sodium bicarbonate may be expected to induce gastrointestinal symptoms including belching and nausea. In addition, high doses of sodium bicarbonate may cause hypernatraemia, electrolytes should be monitored and patients managed accordingly. Administration of N-acetylcysteine or methionine may be required.
